If you’re living with knee or joint pain from osteoarthritis, you know how frustrating it can be. Walking, climbing stairs, or even getting out of bed can become a challenge.
You’have probably tried medications, physiotherapy or injections like hyaluronic acid, and while they help for a while, the pain often returns.
That’s where nSTRIDE APS injection comes in. It’s a new treatment designed to use your own blood to help calm down inflammation inside the joint and protect the cartilage. In simple terms, it helps your body fight the joint inflammation that causes pain.
Clinical Transparency & Regulatory Notice
Regarding Platelet-Rich Plasma (PRP) and Autologous Protein Solution (APS) Treatments:
The Ministry of Health (MOH) in Singapore has issued a consultation paper (Circular No. 56/2026) proposing potential modifications to licence conditions regarding the clinical provision and governance of orthopaedic biologic therapies, including PRP for low-grade knee osteoarthritis and APS.
Please note that these proposals are currently under administrative review and are not yet in final legal effect. Our practice is actively engaged in the formal consultation process to ensure that evidence-based, minimally invasive treatment options remain accessible to appropriate patients.
All treatments at our clinic are administered following a thorough individual clinical evaluation, detailed informed consent regarding current clinical evidence and uncertainties, and in strict adherence to established regulatory standards. We are committed to patient safety and transparent clinical communication.
If you have questions about how these evolving guidelines may apply to your specific condition, please schedule a consultation with our specialists. We will provide an update once MOH has given us a formal reply to our written representation to them.
The Ministry of Health (MOH) in Singapore has issued a consultation paper (Circular No. 56/2026) proposing potential modifications to licence conditions regarding the clinical provision and governance of orthopaedic biologic therapies, including PRP for low-grade knee osteoarthritis and APS.
Please note that these proposals are currently under administrative review and are not yet in final legal effect. Our practice is actively engaged in the formal consultation process to ensure that evidence-based, minimally invasive treatment options remain accessible to appropriate patients.
All treatments at our clinic are administered following a thorough individual clinical evaluation, detailed informed consent regarding current clinical evidence and uncertainties, and in strict adherence to established regulatory standards. We are committed to patient safety and transparent clinical communication.
If you have questions about how these evolving guidelines may apply to your specific condition, please schedule a consultation with our specialists. We will provide an update once MOH has given us a formal reply to our written representation to them.
What Exactly is nSTRIDE APS?
nSTRIDE APS stands for Autologous Protein Solution. “Autologous” simply means it comes from your own body.
Here’s how it works:
A small sample of your blood is taken — about the same amount as a routine blood test.
The blood is processed in a special system that separates out the healing and anti-inflammatory proteins.
This concentrated solution is then injected into your painful joint (usually the knee, but it is also applicable to other joints like the hip and ankle).
The whole process takes less than 30 minutes and is done in the clinic, with no surgery and no hospital stay.
How Does It Help?
In osteoarthritis, the joint becomes inflamed because of certain chemicals like interleukin-1 (IL-1) and TNF-alpha. These are the troublemakers that damage cartilage and cause swelling and pain.
The nSTRIDE APS injection is rich in natural blockers that neutralize these harmful chemicals. By doing so, it helps to:
- Reduce inflammation
- Ease pain and stiffness
- Support cartilage health
Some studies even show that it may slow down further cartilage damage, giving the joint a better environment to stay healthy.
What Can You Expect?
Most patients notice that their pain and mobility improve within a few weeks.
Clinical studies have found that one injection can provide relief lasting up to two or even three years in some people. That’s much longer than the effects of steroid or hyaluronic acid injections.
Of course, results vary from person to person — but for many, it’s been a way to stay active and delay the need for surgery.
Is nSTRIDE APS Safe?
Yes. Because nSTRIDE APS uses your own blood, it’s very safe and natural.
The most common side effect is mild soreness or swelling at the injection site, which usually settles in a few days. There’s no risk of allergy or rejection.
Who Is It For?
nSTRIDE APS may be a good option if you:
- Have mild to moderate osteoarthritis (especially of the knee)
- Have tried other conservative treatments without lasting relief
- Want to delay or avoid joint replacement surgery
Your doctor will usually assess your symptoms and imaging before deciding if you’re a good candidate.
Final Thoughts on nSTRIDE APS Injection
nSTRIDE APS is part of a new generation of biologic treatments that help your joints heal naturally.
It doesn’t just mask pain. It works on the root cause of inflammation and helps protect your cartilage.
For many patients, it means less pain, better movement, and a more active life again.
To learn more about nSTRIDE APS Injection, speak to our orthopaedic specialists at Pinnacle Orthopaedic Group in Singapore.